The Gene Editing Institute is the only research institute of its kind in the nation based within a community health care system. Led by gene editing pioneer, Eric Kmiec, Ph.D., and based in ChristianaCare's Helen F. Graham Cancer Center & Research Institute, the Gene Editing Institute is a worldwide leader in gene editing biomedical research in cancer and other inherited diseases, and the only one working in the same space with oncologists, genetic counselors and patients, bringing translational research from basic science to patient treatment to an entirely new level.
ChristianaCare is currently seeking a Sr. Research Scientist - Preclinical Research Lead for the Gene Editing Institute at our Helen F Graham Cancer Center. The Sr. Research Scientist I will lead preclinical non-small cell lung cancer (NSCLC) research projects in the Oncology group and in collaboration with other teams within the Gene Editing Institute. The Oncology group in the Gene Editing Institute focuses on the development of new, targeted delivery system utilizing AAV-CRISPR/Cas to treat NSCLC in combination with chemotherapy. As a group leader, the Senior Research scientist will expand current preclinical research built on the proof-of-concept studies to successfully file INDs with FDA. The ideal candidate will have advanced and hands on expertise in CRISPR gene therapy and extensive industrial experience in leading a team of scientists to bring about tangible outcomes in timely delivery of therapeutic products.
Other responsibilities include:
Lead preclinical research in NSCLC gene therapeutic drug development
Develop and implement proof-of-concept and preclinical research in other solid tumor gene therapy
Hands on laboratory research in cancer biology, CRISPR technology, AAV biology and other delivery system
Manage the overall progress of the preclinical programs to be aligned with set timelines
Identify and manage Contract Research Organizations for timely execution of projects.
Work with cross-functional team to support the IND submissions
Take Lead role in writing or contracting out nonclinical reports to include in Module 4 of the IND
Support pIND and other meetings with the FDA
Requirements: PhD in oncology, molecular biology, cell biology, biochemistry, or a closely related field. Six to ten years of pharmaceutical industry experience in gene therapeutic development, preclinical and clinical researches. Must be proficient in CRISPR gene therapeutic development, AAV delivery (and/or nonviral vector delivery systems), CRISPR technology and its clinical application, cell-based models and in utilization of murine models, and performing cell biology, biochemistry, and molecular biology techniques.
Internal Number: JR53996
About Christiana Care Health System
Christiana Care Health System is headquartered in Wilmington, Delaware and is one of the country's largest health care providers, ranking 21st in the nation for hospital admissions. Christiana Care is proudly a Nurse Magnet recognized institution. Christiana Care Health System is also one of the largest health care providers in the mid-Atlantic region, serving all of Delaware and portions of seven counties bordering the state in Pennsylvania, Maryland and New Jersey. A not-for-profit, non-sectarian health system, Christiana Care includes two hospitals with more than 1,100 patient beds, and is a major teaching hospital with two campuses. Christiana Care is continually recognized for excellence on a regional and national level. Our role in the community is expressed in the Christiana Care Way: "We serve our neighbors as respectful, expert, caring partners in their health. We do this by creating innovative, effective, affordable systems of care that our neighbors value."Christiana Care is a great place to work because we value diversity and recognize it to be a core part of our success. Because of the diversity of our employees, affiliated health professionals and volunteers, we are... positioned to meet the unique needs of our patients and community. We acknowledge and celebrate the uniqueness and talent of each employee. Because of our talented workforce we are able to provide a quality healthcare experience to our patients and community. We strive to create an inclusive environment in which individual diversity can be leveraged and thrive. Christiana Care Health System is an equal opportunity employer, firmly committed to prohibiting discrimination, whose staff is reflective of its community and considers qualified applicants for open positions without regard to race, color, sex, religion, national origin, sexual orientation, genetic information, gender identity or expression, age, veteran status, disability, pregnancy, citizenship status, or any other characteristic protected under applicable federal, state, or local law.